It's never too soon to treat rheumatoid arthritis: finally, some supportive evidence

Promotion of cardiovascular health at three stages of life: never too soon, never too late.

Cardiovascular disease is the leading cause of death worldwide, with an especially devastating impact in low-to-medium income countries. Cardiovascular disease has been elevated to this position by a combination of factors that include urbanization and its attendant effects, such as obesity, a sedentary lifestyle, changes in dietary habits, and smoking. Given the enormous extent of the problem ...

'Rac'-ing upstream to treat rheumatoid arthritis

Signal transduction pathways regulate the production and function of many cytokines implicated in immune-mediated diseases. Targeting these enzymes with small molecule inhibitors represents a fertile field for the treatment of rheumatoid arthritis. Recent successes with compounds that block upstream kinases suggest that proximal members of the signaling cascades, such as Rac and other Rho famil...

Rheumatoid arthritis classification criteria - It's finally time to move on!

The diagnosis of rheumatoid arthritis (RA) is often challenging, due to a wide spectrum of presentations, progressive changes in disease course over time, and, perhaps, most importantly, lack of a clinical or laboratory gold standard to define the presence or absence of disease. Several attempts at the creation of RA classification criteria have been undertaken; however, each time, there have b...

It's too soon to know.

As I read the paper "Sector Resection With or Without Postoperative Radiotherapy for Stage I Breast Cancer: A Randomized Trial," by Holmberg and colleagues (/), I found myself distressed that it had been accepted for publication, since I believe that it is premature to make the interpretations for which the study was designed and that the authors make. While not changing my view on premature in...

No heroic measures: how soon is too soon to stop?